| pubmed-article:16181731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0460004 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16181731 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16181731 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16181731 | pubmed:dateCreated | 2006-7-3 | lld:pubmed |
| pubmed-article:16181731 | pubmed:abstractText | The activities of insulin-like growth factors (IGFs) in regulating cell proliferation, differentiation, and apoptosis are modulated by a family of high-affinity specific IGF-binding proteins (IGFBPs), IGFBP-3 being the most abundant in circulation. Down-regulation of IGFBP-3 has been shown to be associated with a shorter disease-specific survival probability in early non-small-cell lung cancer (NSCLC). We examined the prognostic role of IGFBP-3 protein expression loss in 34 squamous cell carcinomas (SCC) of the tongue (stages II-IV) and 30 premalignant lesions of the oral cavity and the larynx. Reduced IGFBP-3 expression was found in 11 (32%) of 34 tongue SCC cases, and was associated with significantly shorter disease-specific and disease-free survival (P=0.0002 and <0.0001 by Log-rank test). In premalignant lesions, IGFBP3 loss was found in 8 (27%) of 30 cases without significant association with cancer-free survival. Therefore, down-regulation of IGFBP-3 is an early event during head and neck carcinogenesis, that bears an adverse prognostic significance in tongue cancer and could serve as both a marker of aggressive disease and target for intervention. | lld:pubmed |
| pubmed-article:16181731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16181731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16181731 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16181731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16181731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16181731 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16181731 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:HongWaun KiWK | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:LiuDiane DDD | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:El-NaggarAdel... | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:LeeHo-YoungHY | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:Papadimitrako... | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:BrownErika... | lld:pubmed |
| pubmed-article:16181731 | pubmed:author | pubmed-author:Jack LeeJJ | lld:pubmed |
| pubmed-article:16181731 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16181731 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:16181731 | pubmed:volume | 239 | lld:pubmed |
| pubmed-article:16181731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16181731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16181731 | pubmed:pagination | 136-43 | lld:pubmed |
| pubmed-article:16181731 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
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| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
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| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:meshHeading | pubmed-meshheading:16181731... | lld:pubmed |
| pubmed-article:16181731 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16181731 | pubmed:articleTitle | The prognostic role of loss of insulin-like growth factor-binding protein-3 expression in head and neck carcinogenesis. | lld:pubmed |
| pubmed-article:16181731 | pubmed:affiliation | Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. vpapadim@mdanderson.org | lld:pubmed |
| pubmed-article:16181731 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16181731 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3486 | entrezgene:pubmed | pubmed-article:16181731 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16181731 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16181731 | lld:pubmed |
