| pubmed-article:16175596 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C0524910 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:16175596 | lifeskim:mentions | umls-concept:C1512948 | lld:lifeskim |
| pubmed-article:16175596 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16175596 | pubmed:dateCreated | 2005-9-26 | lld:pubmed |
| pubmed-article:16175596 | pubmed:abstractText | The precise mechanisms responsible for the failure of intrahepatic hepatitis C virus (HCV)-specific CD8+ T cells to control the virus during persistent infection have not been fully defined. We therefore studied the CD8+ T-cell response in 27 HLA-A2-positive patients using four previously well-defined HLA-A2-restricted HCV epitopes. The corresponding HCV sequences were determined in several patients and compared with the intrahepatic HCV-specific CD8+ T-cell response. The results of the study indicate: (1) intrahepatic HCV-specific CD8+ T cells are present in the majority of patients with chronic HCV infection and overlap significantly with the response present in the peripheral blood. (2) A large fraction of intrahepatic HCV-specific CD8+ T cells are impaired in their ability to secrete interferon gamma (IFN-gamma). This dysfunction is specific for HCV-specific CD8+ T cells, since intrahepatic Flu-specific CD8+ T cells readily secrete this cytokine. (3) T-cell selection of epitope variants may have occurred in some patients. However, it is not an inevitable consequence of a functional virus-specific CD8+ T-cell response, since several patients with IFN-gamma-producing CD8+ T-cell responses harbored HCV sequences identical or cross-reactive with the prototype sequence. (4) The failure of intrahepatic virus-specific CD8+ T cells to sufficiently control the virus occurs despite the presence of virus-specific CD4+ T cells at the site of disease. In conclusion, different mechanisms contribute to the failure of intrahepatic CD8+ T cells to eliminate HCV infection, despite their persistence and accumulation in the liver. | lld:pubmed |
| pubmed-article:16175596 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16175596 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16175596 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16175596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16175596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16175596 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16175596 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16175596 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:BlumHubert... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:RoggendorfMic... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:ViazovSergeiS | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:McKinneyDenis... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:ThimmeRobertR | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:SpangenbergHa... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:Neumann-Haefe... | lld:pubmed |
| pubmed-article:16175596 | pubmed:author | pubmed-author:KerstingNadin... | lld:pubmed |
| pubmed-article:16175596 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16175596 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:16175596 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16175596 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16175596 | pubmed:pagination | 828-37 | lld:pubmed |
| pubmed-article:16175596 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16175596 | pubmed:meshHeading | pubmed-meshheading:16175596... | lld:pubmed |
| pubmed-article:16175596 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16175596 | pubmed:articleTitle | Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. | lld:pubmed |
| pubmed-article:16175596 | pubmed:affiliation | Department of Medicine II, University Hospital Freiburg, Freiburg, Germany. | lld:pubmed |
| pubmed-article:16175596 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16175596 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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