Linked Life Data

16174656

Source:http://linkedlifedata.com/resource/pubmed/id/16174656

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pubmed-article:16174656pubmed:dateCreated2005-12-12lld:pubmed
pubmed-article:16174656pubmed:abstractTextThe aim of the present study was to evaluate the effect of prolonged inhibition of beta-oxidation on glucose and lipid muscle forearm metabolism and cGMP and endothelin-1 forearm release in patients with type 2 diabetes mellitus and ischemic cardiomyopathy. Fifteen patients were randomly allocated in a double-blind cross-over parallel study with trimetazidine (20 mg tid) or placebo lasting 15 days. At the end of each period, all patients underwent euglycemic hyperinsulinemic clamps with forearm indirect calorimetry and endothelial balance of vasodilator and vasoconstricor factors. Compared with placebo, trimetazidine induced 1) an increase in insulin-induced forearm glucose uptake and glucose oxidation accompanied by a reduction in forearm lipid oxidation and citrate release and 2) a decrease of endothelin-1 release paralleled by a significant increase in forearm cGMP release. Forearm glucose oxidation significantly correlated with cGMP release (r=0.37, P<0.04), whereas forearm lipid oxidation positively correlated with endothelin-1 release (r=0.40, P<0.03). In conclusion, for the first time, we demonstrated that insulin-induced forearm glucose oxidation and forearm cGMP release were increased whereas forearm endothelin-1 release was decreased during trimetazidine treatment. Muscle's metabolic and vascular effects of trimetazidine add new interest in the use of trimetazidine in type 2 diabetic patients with cardiovascular disease.lld:pubmed
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pubmed-article:16174656pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:16174656pubmed:year2006lld:pubmed
pubmed-article:16174656pubmed:articleTitleMetabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.lld:pubmed
pubmed-article:16174656pubmed:affiliationLaboratory L20, Core Lab., Diabetology, Endocrinology and Metabolic Disease Unit, IRCCS H San Raffaele, Via Olgettina 60, 20132 Milan, Italy. monti.lucilla@hsr.itlld:pubmed
pubmed-article:16174656pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16174656pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:16174656pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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