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pubmed-article:16170078pubmed:abstractTextThe cytokine interleukin (IL)-1 mediates ischaemic brain damage in rodents. The endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against ischaemic cerebral injury in a range of experimental settings, and IL-1ra causes a marked reduction of cell death when administered peripherally or at a delay in transient cerebral ischaemia. We report here the first randomised, double blind, placebo controlled trial of recombinant human IL-1ra (rhIL-1ra) in patients with acute stroke.lld:pubmed
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pubmed-article:16170078pubmed:articleTitleA randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients.lld:pubmed
pubmed-article:16170078pubmed:affiliationDivision of Neuroscience, The University of Liverpool, The Walton Centre for Neurology & Neurosurgery, Liverpool, UK.lld:pubmed
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