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pubmed-article:16169219pubmed:abstractTextThe semi-synthesis, in vitro and in vivo biological evaluation of corosolic acid (1) and maslinic acid (2) are described. Compounds 1 and 2 represent a new class of inhibitors of glycogen phosphorylases. Both 1 and 2 inhibit the increase of fasted plasma glucose of diabetic mice induced by adrenaline. It is therefore proposed that naturally occurring pentacyclic triterpenes 1 and 2 might reduce blood glucose, at least in part, through inhibiting hepatic glycogen degradation.lld:pubmed
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pubmed-article:16169219pubmed:authorpubmed-author:WuXiaomingXlld:pubmed
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pubmed-article:16169219pubmed:articleTitlePentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases.lld:pubmed
pubmed-article:16169219pubmed:affiliationDepartment of Medicinal Chemistry, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.lld:pubmed
pubmed-article:16169219pubmed:publicationTypeJournal Articlelld:pubmed
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