| pubmed-article:16148050 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0225698 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0005740 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16148050 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16148050 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16148050 | pubmed:dateCreated | 2005-9-8 | lld:pubmed |
| pubmed-article:16148050 | pubmed:abstractText | Exposure to bleomycin in rodents induces lung injury and fibrosis. Alveolar epithelial cell death has been hypothesized as an initiating mechanism underlying bleomycin-induced lung injury and fibrosis. In the present study we evaluated the contribution of mitochondrial and receptor-meditated death pathways in bleomycin-induced death of mouse alveolar epithelial cells (MLE-12 cells) and primary rat alveolar type II cells. Control MLE-12 cells and primary rat alveolar type II cells died after 48 h of exposure to bleomycin. Both MLE-12 cells and rat alveolar type II cells overexpressing Bcl-X(L) did not undergo cell death in response to bleomycin. Dominant negative Fas-associating protein with a death domain failed to prevent bleomycin-induced cell death in MLE-12 cells. Caspase-8 inhibitor CrmA did not prevent bleomycin-induced cell death in primary rat alveolar type II cells. Furthermore, fibroblast cells deficient in Bax and Bak, but not Bid, were resistant to bleomycin-induced cell death. To determine whether the stress kinase JNK was an upstream regulator of Bax activation, MLE-12 cells were exposed to bleomycin in the presence of an adenovirus encoding a dominant negative JNK. Bleomycin-induced Bax activation was prevented by the expression of a dominant negative JNK in MLE-12 cells. Dominant negative JNK prevented cell death in MLE-12 cells and in primary rat alveolar type II cells exposed to bleomycin. These data indicate that bleomycin induces cell death through a JNK-dependent mitochondrial death pathway in alveolar epithelial cells. | lld:pubmed |
| pubmed-article:16148050 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16148050 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16148050 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16148050 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16148050 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:KanetoHideaki... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:LeeVivian YVY | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:BudingerG R... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:ChandelNavdee... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:SchroedlClara... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:BuccellatoLeo... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:AkinciOzkan... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:BrunelleJosly... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:EisenbartJame... | lld:pubmed |
| pubmed-article:16148050 | pubmed:author | pubmed-author:SnyderColleen... | lld:pubmed |
| pubmed-article:16148050 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16148050 | pubmed:volume | 289 | lld:pubmed |
| pubmed-article:16148050 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16148050 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16148050 | pubmed:pagination | L521-8 | lld:pubmed |
| pubmed-article:16148050 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:meshHeading | pubmed-meshheading:16148050... | lld:pubmed |
| pubmed-article:16148050 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16148050 | pubmed:articleTitle | Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway. | lld:pubmed |
| pubmed-article:16148050 | pubmed:affiliation | Div. of Pulmonary & Critical Care, Northwestern University, Chicago, IL 60611, USA. | lld:pubmed |
| pubmed-article:16148050 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16148050 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16148050 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16148050 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16148050 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16148050 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16148050 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16148050 | lld:pubmed |
