| pubmed-article:16141310 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C0311404 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C2610891 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:16141310 | lifeskim:mentions | umls-concept:C1506009 | lld:lifeskim |
| pubmed-article:16141310 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16141310 | pubmed:dateCreated | 2005-11-18 | lld:pubmed |
| pubmed-article:16141310 | pubmed:abstractText | Sulfated polymannuroguluronate (SPMG) has entered the phase II clinical trial as the first anti-AIDS drug candidate in China. Herein, we report that SPMG was effective at protecting T lymphocytes against apoptosis. Further studies indicated that SPMG significantly elevated mitochondrial membrane potential (MMP) of T cells; inhibited mitochondrial release of cytochrome c (cyto c) in T cells; enhanced the activities of mitochondrial enzyme complex I, III, and V; and subsequently increased ATP level and ATP/ADP ratio. In addition, SPMG potently suppressed reactive oxygen species (ROS) generation in mitochondria at cellular level and scavenged free radicals in cell-free system. The molecular mechanism underlying the ATP-involved and ROS-dependent antiapoptosis of SPMG is characterized as having been caused by its engagement with mitochondrial import receptor and ADP/ATP carrier in T-cell outer and inner mitochondrial membrane, respectively. All these might shed new light on the understanding of anti-AIDS functions of SPMG by protecting T cells of persons infected with human immunodeficiency virus. | lld:pubmed |
| pubmed-article:16141310 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16141310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16141310 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16141310 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16141310 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:IkiNN | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:LiJingJ | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:GengMeiyuM | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:XianliangXinX | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:MiaoBenchunB | lld:pubmed |
| pubmed-article:16141310 | pubmed:author | pubmed-author:FuXueyanX | lld:pubmed |
| pubmed-article:16141310 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16141310 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:16141310 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16141310 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16141310 | pubmed:pagination | 1716-27 | lld:pubmed |
| pubmed-article:16141310 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16141310 | pubmed:meshHeading | pubmed-meshheading:16141310... | lld:pubmed |
| pubmed-article:16141310 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16141310 | pubmed:articleTitle | Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, inhibits T cell apoptosis by combating oxidative damage of mitochondria. | lld:pubmed |
| pubmed-article:16141310 | pubmed:affiliation | Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, People's Republic of China. | lld:pubmed |
| pubmed-article:16141310 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16141310 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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