| pubmed-article:16140768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0086427 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:16140768 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16140768 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16140768 | pubmed:dateCreated | 2005-9-5 | lld:pubmed |
| pubmed-article:16140768 | pubmed:abstractText | Human T-cell leukemia virus type 1 (HTLV-1) but not HTLV-2 is associated with adult T-cell leukemia. We found that HTLV-2 Tax2 protein stimulated reporter gene expression regulated by the interleukin (IL)-2 promoter through the nuclear factor of activated T cells (NFAT) in a human T-cell line (Jurkat). However, the activity of HTLV-1 Tax1 was minimal in this system. T-cell lines immortalized by HTLV-2 but not HTLV-1 constitutively exhibited activated NFAT in the nucleus and constitutively expressed IL-2 mRNA. Cyclosporine A, an inhibitor of NFAT activation, abrogated the induction of IL-2 mRNA in HTLV-2-immortalized T-cell lines and concomitantly inhibited cell growth. This growth inhibition was rescued by the addition of IL-2 to the culture. Furthermore, anti-IL-2 receptor antibodies significantly reduced the proliferation of HTLV-2-infected T-cell lines but not that of HTLV-1-infected cells. Our results suggest that Tax2 activates an IL-2 autocrine loop mediated through NFAT that supports the growth of HTLV-2-infected cells under low-IL-2 conditions. This mechanism would be especially important in vivo, where this autocrine mechanism establishes a nonleukemogenic life-long HTLV-2 infection. The results also suggest that differences in long-term cytokine production between HTLV-1 and HTLV-2 infection are another factor for the differences in pathogenesis. | lld:pubmed |
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| pubmed-article:16140768 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16140768 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16140768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16140768 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16140768 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:FuZ LZL | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:SugamuraKazuo... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:TakahashiMasa... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:HiguchiMasaya... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:TanakaYuetsuY | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:TanakaNobuyuk... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:GejyoFumitake... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:OieMasayasuM | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:FujiiMasahiro... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:GreenPatrick... | lld:pubmed |
| pubmed-article:16140768 | pubmed:author | pubmed-author:NiinumaAkikoA | lld:pubmed |
| pubmed-article:16140768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16140768 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:16140768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16140768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16140768 | pubmed:pagination | 11925-34 | lld:pubmed |
| pubmed-article:16140768 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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