| pubmed-article:16136051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C1513276 | lld:lifeskim |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C1708790 | lld:lifeskim |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C1880916 | lld:lifeskim |
| pubmed-article:16136051 | lifeskim:mentions | umls-concept:C1569815 | lld:lifeskim |
| pubmed-article:16136051 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16136051 | pubmed:dateCreated | 2005-10-13 | lld:pubmed |
| pubmed-article:16136051 | pubmed:abstractText | The monoclonal antibody D2-40 is a specific lymphatic endothelial markers and D2-40 staining have been applicable to evaluate lymphatic invasion in various malignant neoplasms. In the present study, we investigated lymph node micrometastasis determined by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) in all dissected lymph nodes obtained from 80 patients with node-negative gastric cancer, and analysed the relationship between micrometastasis and clinicopathological findings including lymphatic invasion of the resected primary tumour using D2-40 immunohistochemical staining. The incidence of micrometastasis determined by IHC and RT-PCR was 11.3% (nine out of 80) and 31.3% (25 out of 80), respectively. Although haematoxylin-eosin (HE) staining revealed lymphatic invasion in 11.3% (nine out of 80) of patients, D2-40 staining uncovered new invasion in 23.8% (19 out of 80) of patients. In the diagnosis of HE and D2-40 staining, the incidence of micrometastasis was significantly higher in patients with lymphatic invasion than in those without lymphatic invasion (P=0.0150 and P<0.0001, respectively). Micrometastasis correlated more closely with D2-40 than with HE staining. We demonstrated a high incidence of micrometastasis and lymphatic invasion and a correlation between them even in pN0 gastric cancer. When planning less invasive treatment, the presence of such occult cancer cells should be considered. | lld:pubmed |
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| pubmed-article:16136051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16136051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16136051 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16136051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16136051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16136051 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16136051 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:IshigamiSS | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:ArimaHH | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:YanagidaSS | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:NatsugoeSS | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:AikouTT | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:HokitaSS | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:MatakiYY | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:UenosonoYY | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:HanQiQ | lld:pubmed |
| pubmed-article:16136051 | pubmed:author | pubmed-author:ArigamiTT | lld:pubmed |
| pubmed-article:16136051 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16136051 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:16136051 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:16136051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16136051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16136051 | pubmed:pagination | 688-93 | lld:pubmed |
| pubmed-article:16136051 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
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| pubmed-article:16136051 | pubmed:meshHeading | pubmed-meshheading:16136051... | lld:pubmed |
| pubmed-article:16136051 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16136051 | pubmed:articleTitle | Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer. | lld:pubmed |
| pubmed-article:16136051 | pubmed:affiliation | Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. arigami@m.kufm.kagoshima-u.ac.jp | lld:pubmed |
| pubmed-article:16136051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16136051 | pubmed:publicationType | Comparative Study | lld:pubmed |
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