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| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
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| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C0879262 | lld:lifeskim |
| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:16134238 | lifeskim:mentions | umls-concept:C0596581 | lld:lifeskim |
| pubmed-article:16134238 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16134238 | pubmed:dateCreated | 2005-8-30 | lld:pubmed |
| pubmed-article:16134238 | pubmed:abstractText | To examine the effect of an oral fluoropyrimidine anti-cancer agent (S-1) on the radiosensitivity of a human oral cancer cell line with focusing on inhibition of survival signal, Akt/PKB. A human oral cell cancer cell line B88 was used. Activation of Akt/PKB in vivo was examined by immunohistochemistry, and apoptotic cells were detected by TUNEL method. Activation of Akt/PKB in vitro was investigated by Western blot and ELISA, and apoptotic cells were detected by Hoechst 33258 staining. S-1 (10 mg/kg/day or 50 microg/ml) greatly enhanced radiosensitivity in B88 cells by suppressing the activation of Akt/PKB. Significant increase in the percentage of apoptotic cells was observed in S-1 treated B88 cells. Survival signals Akt/PKB may be involved in determining radiosensitivity. S-1, an oral fluoropyrimidine anti-cancer agent can exert the enhancing effect on radiation by suppressing the activation of Akt/PKB. | lld:pubmed |
| pubmed-article:16134238 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16134238 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16134238 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16134238 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16134238 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:YoshidaHideoH | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:SatoMitsunobu... | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:HaradaKojiK | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:Supriatno | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:KawaguchiShin... | lld:pubmed |
| pubmed-article:16134238 | pubmed:author | pubmed-author:KawashimaYuic... | lld:pubmed |
| pubmed-article:16134238 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16134238 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:16134238 | pubmed:volume | 226 | lld:pubmed |
| pubmed-article:16134238 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16134238 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16134238 | pubmed:pagination | 161-168 | lld:pubmed |
| pubmed-article:16134238 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16134238 | pubmed:meshHeading | pubmed-meshheading:16134238... | lld:pubmed |
| pubmed-article:16134238 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16134238 | pubmed:articleTitle | S-1, an oral fluoropyrimidine anti-cancer agent, enhanced radiosensitivity in a human oral cancer cell line in vivo and in vitro: involvement possibility of inhibition of survival signal, Akt/PKB. | lld:pubmed |
| pubmed-article:16134238 | pubmed:affiliation | Second Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan. harako@dent.tokushima-u.ac.jp | lld:pubmed |
| pubmed-article:16134238 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16134238 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16134238 | lld:pubmed |
