| pubmed-article:16123342 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16123342 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:16123342 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:16123342 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:16123342 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:16123342 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16123342 | pubmed:dateCreated | 2005-8-26 | lld:pubmed |
| pubmed-article:16123342 | pubmed:abstractText | A number of studies and clinical case reports have implicated interferon (IFN)-alpha as a potential mediator of type 1 diabetes pathogenesis. Administration of polyinosinic:polycytidylic acid (poly I:C), a mimic of viral double-stranded RNA, induces diabetes in C57BL/6 mice expressing the B7.1 costimulatory molecule in islets. We investigated the potential role of IFN-alpha in this disease model. The quantitative correlation between IFN-alpha levels and time to diabetes, diabetes prevention with anti-IFN-alpha antibody, and ability of IFN-alpha itself to induce diabetes are consistent with the hypothesis that poly I:C in this model acts by induction of IFN-alpha in a genetically susceptible host. Numerous recent studies highlight the importance of the innate immune system and toll receptors in determining adaptive immune responses, and we speculate that for type 1 diabetes, viral and other environmental factors may act through induction of IFNs. | lld:pubmed |
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| pubmed-article:16123342 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16123342 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16123342 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:16123342 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16123342 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16123342 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16123342 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:RachevS GSG | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:EisenbarthGeo... | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:MiaoDongmeiD | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:MoriyamaHiroa... | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:LiuEdwinE | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:NakayamaMakiM | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:DevendraDevas... | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:ParonenJohann... | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:LiMarcellaM | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:JasinskiJeanJ | lld:pubmed |
| pubmed-article:16123342 | pubmed:author | pubmed-author:HensleyBrooke... | lld:pubmed |
| pubmed-article:16123342 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16123342 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:16123342 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16123342 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16123342 | pubmed:pagination | 2549-56 | lld:pubmed |
| pubmed-article:16123342 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16123342 | pubmed:meshHeading | pubmed-meshheading:16123342... | lld:pubmed |
| pubmed-article:16123342 | pubmed:meshHeading | pubmed-meshheading:16123342... | lld:pubmed |
| pubmed-article:16123342 | pubmed:meshHeading | pubmed-meshheading:16123342... | lld:pubmed |
| pubmed-article:16123342 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16123342 | pubmed:articleTitle | Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. | lld:pubmed |
| pubmed-article:16123342 | pubmed:affiliation | Barbara Davis Center for Childhood Diabetes, 4200 East 9th Ave., Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA. edwin.liu@uchsc.edu | lld:pubmed |
| pubmed-article:16123342 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16123342 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16123342 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16123342 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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