| pubmed-article:16116445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16116445 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:16116445 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:16116445 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:16116445 | lifeskim:mentions | umls-concept:C0451615 | lld:lifeskim |
| pubmed-article:16116445 | lifeskim:mentions | umls-concept:C0681890 | lld:lifeskim |
| pubmed-article:16116445 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16116445 | pubmed:dateCreated | 2005-8-29 | lld:pubmed |
| pubmed-article:16116445 | pubmed:abstractText | Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats relief in a similar way as it treats natural reward is unclear, and the neural processes that underlie its representation as a motivational goal remain poorly understood. We used fMRI (functional magnetic resonance imaging) to investigate how humans learn to generate expectations of pain relief. Using a pavlovian conditioning procedure, we show that subjects experiencing prolonged experimentally induced pain can be conditioned to predict pain relief. This proceeds in a manner consistent with contemporary reward-learning theory (average reward/loss reinforcement learning), reflected by neural activity in the amygdala and midbrain. Furthermore, these reward-like learning signals are mirrored by opposite aversion-like signals in lateral orbitofrontal cortex and anterior cingulate cortex. This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain. | lld:pubmed |
| pubmed-article:16116445 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16116445 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16116445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16116445 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16116445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16116445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16116445 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16116445 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:FristonKarlK | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:FrackowiakRic... | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:O'DohertyJohn... | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:KoltzenburgMa... | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:WiechKatjaK | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:SeymourBenB | lld:pubmed |
| pubmed-article:16116445 | pubmed:author | pubmed-author:DolanRaymondR | lld:pubmed |
| pubmed-article:16116445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16116445 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16116445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16116445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16116445 | pubmed:pagination | 1234-40 | lld:pubmed |
| pubmed-article:16116445 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:16116445 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16116445 | pubmed:articleTitle | Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. | lld:pubmed |
| pubmed-article:16116445 | pubmed:affiliation | Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK. bseymour@fil.ion.ucl.ac.uk | lld:pubmed |
| pubmed-article:16116445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16116445 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16116445 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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