Linked Life Data

16107968

Source:http://linkedlifedata.com/resource/pubmed/id/16107968

Statements in which the resource exists.
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pubmed-article:16107968pubmed:abstractTextVariant surface antigens (VSA) on Plasmodium falciparum-infected erythrocytes are potentially important targets of immunity to malaria. We previously identified a VSA phenotype--VSA with a high frequency of antibody recognition (VSA(FoRH))--that is associated with young host age and severe malaria. We hypothesized that VSA(FoRH) are positively selected by host molecules such as intercellular adhesion molecule 1 (ICAM1) and CD36 and dominate in the absence of an effective immune response. Here, we assessed, in 115 Kenyan children, the potential role played by in vivo selection pressures in either favoring or selecting against VSA(FoRH) among parasites that cause malaria.lld:pubmed
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pubmed-article:16107968pubmed:authorpubmed-author:RobertsDavid...lld:pubmed
pubmed-article:16107968pubmed:authorpubmed-author:BullPeter CPClld:pubmed
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pubmed-article:16107968pubmed:pagination1119-26lld:pubmed
pubmed-article:16107968pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:16107968pubmed:year2005lld:pubmed
pubmed-article:16107968pubmed:articleTitlePlasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity.lld:pubmed
pubmed-article:16107968pubmed:affiliationNuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. pbull@kilifi.mimcom.netlld:pubmed
pubmed-article:16107968pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16107968pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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