| pubmed-article:16094458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16094458 | lifeskim:mentions | umls-concept:C1274041 | lld:lifeskim |
| pubmed-article:16094458 | lifeskim:mentions | umls-concept:C0019397 | lld:lifeskim |
| pubmed-article:16094458 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:16094458 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:16094458 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16094458 | pubmed:dateCreated | 2005-8-11 | lld:pubmed |
| pubmed-article:16094458 | pubmed:abstractText | Lymphoid-specific helicase (Lsh) is a crucial factor for normal embryonic development; targeted deletion of Lsh is lethal. Lsh belongs to a family of chromatin-remodeling proteins and is closely associated with pericentromeric heterochromatin. Lsh deficiency leads to abnormal heterochromatin organization, with a loss of DNA methylation, and an altered pattern of histone-tail acetylation and methylation. As a functional consequence of perturbed heterochromatin, aberrant reactivation of parasitic retroviral elements in the genome and abnormal mitosis with amplified centrosomes and genomic instability were observed. Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function. | lld:pubmed |
| pubmed-article:16094458 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16094458 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16094458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16094458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16094458 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16094458 | pubmed:issn | 0829-8211 | lld:pubmed |
| pubmed-article:16094458 | pubmed:author | pubmed-author:MueggeKathrin... | lld:pubmed |
| pubmed-article:16094458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16094458 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:16094458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16094458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16094458 | pubmed:pagination | 548-54 | lld:pubmed |
| pubmed-article:16094458 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:meshHeading | pubmed-meshheading:16094458... | lld:pubmed |
| pubmed-article:16094458 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16094458 | pubmed:articleTitle | Lsh, a guardian of heterochromatin at repeat elements. | lld:pubmed |
| pubmed-article:16094458 | pubmed:affiliation | Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21701, USA. muegge@mail.ncifcrf.gov | lld:pubmed |
| pubmed-article:16094458 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16094458 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16094458 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16094458 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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