| pubmed-article:16079837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C0231337 | lld:lifeskim |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C0205265 | lld:lifeskim |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C1555582 | lld:lifeskim |
| pubmed-article:16079837 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:16079837 | pubmed:issue | 7051 | lld:pubmed |
| pubmed-article:16079837 | pubmed:dateCreated | 2005-8-4 | lld:pubmed |
| pubmed-article:16079837 | pubmed:abstractText | Acute induction of oncogenic Ras provokes cellular senescence involving the retinoblastoma (Rb) pathway, but the tumour suppressive potential of senescence in vivo remains elusive. Recently, Rb-mediated silencing of growth-promoting genes by heterochromatin formation associated with methylation of histone H3 lysine 9 (H3K9me) was identified as a critical feature of cellular senescence, which may depend on the histone methyltransferase Suv39h1. Here we show that Emicro-N-Ras transgenic mice harbouring targeted heterozygous lesions at the Suv39h1, or the p53 locus for comparison, succumb to invasive T-cell lymphomas that lack expression of Suv39h1 or p53, respectively. By contrast, most N-Ras-transgenic wild-type ('control') animals develop a non-lymphoid neoplasia significantly later. Proliferation of primary lymphocytes is directly stalled by a Suv39h1-dependent, H3K9me-related senescent growth arrest in response to oncogenic Ras, thereby cancelling lymphomagenesis at an initial step. Suv39h1-deficient lymphoma cells grow rapidly but, unlike p53-deficient cells, remain highly susceptible to adriamycin-induced apoptosis. In contrast, only control, but not Suv39h1-deficient or p53-deficient, lymphomas senesce after drug therapy when apoptosis is blocked. These results identify H3K9me-mediated senescence as a novel Suv39h1-dependent tumour suppressor mechanism whose inactivation permits the formation of aggressive but apoptosis-competent lymphomas in response to oncogenic Ras. | lld:pubmed |
| pubmed-article:16079837 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16079837 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16079837 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16079837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16079837 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16079837 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:PetersAntoine... | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:JenuweinThoma... | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:SteinHaraldH | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:DörkenBerndB | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:Schlegelberge... | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:SchmittClemen... | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:LeeSoyoungS | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:LoddenkemperC... | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:BraigMelanieM | lld:pubmed |
| pubmed-article:16079837 | pubmed:author | pubmed-author:RudolphCornel... | lld:pubmed |
| pubmed-article:16079837 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16079837 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:16079837 | pubmed:volume | 436 | lld:pubmed |
| pubmed-article:16079837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16079837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16079837 | pubmed:pagination | 660-5 | lld:pubmed |
| pubmed-article:16079837 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16079837 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16079837 | pubmed:articleTitle | Oncogene-induced senescence as an initial barrier in lymphoma development. | lld:pubmed |
| pubmed-article:16079837 | pubmed:affiliation | Charité-Universitätsmedizin Berlin/Haematology-Oncology, 13353 Berlin, Germany. | lld:pubmed |
| pubmed-article:16079837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16079837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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