| pubmed-article:16004883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C0054836 | lld:lifeskim |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C0340288 | lld:lifeskim |
| pubmed-article:16004883 | lifeskim:mentions | umls-concept:C1158882 | lld:lifeskim |
| pubmed-article:16004883 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16004883 | pubmed:dateCreated | 2005-7-11 | lld:pubmed |
| pubmed-article:16004883 | pubmed:abstractText | Neutrophil superoxide anion (O(2)(*-)) generation was measured during carvedilol therapy in patients with stable angina. The carvedilol group comprised 27 patients (18 men and 9 women), aged 38-51 years (mean 47.6 years) with stable angina. Carvedilol was administered in increased every 4-week doses: 12.5, 25 and 50 mg/24 h, respectively. The control group included 12 healthy subjects, aged 39-49 years (mean 45.7 years) with no drug administered. Blood samples were collected from cubital vein before and 4, 8 and 12 weeks after the therapy and once in the control group. Neutrophil O(2)(*-) generation was determined in whole blood without and with opsonized zymosan (OZ) stimulation according to Bellavite et al. method using superoxide dismutase from bovine erythrocytes. O(2)(*-) generation by nonstimulated and OZ-stimulated neutrophils was significantly higher (p<0.05) in patients with stable angina than in the control group. In carvedilol group, statistically significant (p<0.05) decrease in superoxide anion generation by nonstimulated and OZ-stimulated neutrophils was observed 8 and 12 weeks after the therapy and it did not differ from that in healthy subjects. Carvedilol has been shown to inhibit neutrophil O(2)(*-) generation in patients with stable angina. | lld:pubmed |
| pubmed-article:16004883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16004883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16004883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16004883 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16004883 | pubmed:issn | 0167-5273 | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:B?aszczykJanJ | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:KowalskiJanJ | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:KowalczykEdwa... | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:PeteckaEdytaE | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:PawlickiLucja... | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:Irzma?skiRobe... | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:Cegli?skiToma... | lld:pubmed |
| pubmed-article:16004883 | pubmed:author | pubmed-author:KowalskaEwaE | lld:pubmed |
| pubmed-article:16004883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16004883 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16004883 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:16004883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16004883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16004883 | pubmed:pagination | 397-402 | lld:pubmed |
| pubmed-article:16004883 | pubmed:dateRevised | 2006-7-12 | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
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| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:meshHeading | pubmed-meshheading:16004883... | lld:pubmed |
| pubmed-article:16004883 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16004883 | pubmed:articleTitle | Neutrophils superoxide anion generation during carvedilol therapy in patients with stable angina. | lld:pubmed |
| pubmed-article:16004883 | pubmed:affiliation | Department of Internal Medicine and Cardiological Rehabilitation, Medical University of ?ód?, Poland. | lld:pubmed |
| pubmed-article:16004883 | pubmed:publicationType | Journal Article | lld:pubmed |
