| pubmed-article:15994950 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0115305 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0033578 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C1522484 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0036525 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0253690 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15994950 | lifeskim:mentions | umls-concept:C0249992 | lld:lifeskim |
| pubmed-article:15994950 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:15994950 | pubmed:dateCreated | 2005-7-4 | lld:pubmed |
| pubmed-article:15994950 | pubmed:abstractText | Prostate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding interactions with E-selectin. We hypothesized that E-selectin ligands on prostate tumor cells are directly associated with bone-metastatic potential. In this report, we elucidate the identity of E-selectin ligands on human metastatic prostate tumor cells and examine their association with prostate tumor progression and metastasis in vivo. To our surprise, we found that the E-selectin-binding form of P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on the human bone-metastatic prostate tumor MDA PCa 2b cell line. Interestingly, we also found that human prostate tumor cells derived from bone, lymph node, and brain metastases expressed another leukocyte E-selectin ligand, E-selectin ligand-1 (ESL-1). Immunohistochemical analysis of PSGL-1 and ESL-1 in normal prostate tissue and in localized and metastatic prostate tumors revealed that ESL-1 was principally localized to intracellular cell membrane and expressed on all normal and malignant prostate tissue, whereas PSGL-1 was notably detected on the surfaces of bone-metastatic prostate tumor cells. These findings implicate a functional role of PSGL-1 in the bone tropism of prostate tumor cells and establish a new perspective into the molecular mechanism of human prostate tumor metastasis. | lld:pubmed |
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| pubmed-article:15994950 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15994950 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15994950 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15994950 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15994950 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15994950 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:RubinMark AMA | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:HuangWeiW | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:KutokJeffery... | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:PientaKenneth... | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:DimitroffChar... | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:KimRobertR | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:NguyenVuongV | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:DeschenyLeyla... | lld:pubmed |
| pubmed-article:15994950 | pubmed:author | pubmed-author:TrujilloNatal... | lld:pubmed |
| pubmed-article:15994950 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15994950 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15994950 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:15994950 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15994950 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15994950 | pubmed:pagination | 5750-60 | lld:pubmed |
| pubmed-article:15994950 | pubmed:dateRevised | 2011-9-21 | lld:pubmed |
| pubmed-article:15994950 | pubmed:meshHeading | pubmed-meshheading:15994950... | lld:pubmed |
