| pubmed-article:15987682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0067684 | lld:lifeskim |
| pubmed-article:15987682 | lifeskim:mentions | umls-concept:C0052532 | lld:lifeskim |
| pubmed-article:15987682 | pubmed:issue | 35 | lld:pubmed |
| pubmed-article:15987682 | pubmed:dateCreated | 2005-8-29 | lld:pubmed |
| pubmed-article:15987682 | pubmed:abstractText | Aralar is a mitochondrial calcium-regulated aspartate-glutamate carrier mainly distributed in brain and skeletal muscle, involved in the transport of aspartate from mitochondria to cytosol, and in the transfer of cytosolic reducing equivalents into mitochondria as a member of the malate-aspartate NADH shuttle. In the present study, we describe the characteristics of aralar-deficient (Aralar-/-) mice, generated by a gene-trap method, showing no aralar mRNA and protein, and no detectable malate-aspartate shuttle activity in skeletal muscle and brain mitochondria. Aralar-/- mice were growth-retarded, exhibited generalized tremoring, and had pronounced motor coordination defects along with an impaired myelination in the central nervous system. Analysis of lipid components showed a marked decrease in the myelin lipid galactosyl cerebroside. The content of the myelin lipid precursor, N-acetylaspartate, and that of aspartate are drastically decreased in the brain of Aralar-/- mice. The defect in N-acetylaspartate production was also observed in cell extracts from primary neuronal cultures derived from Aralar-/- mouse embryos. These results show that aralar plays an important role in myelin formation by providing aspartate for the synthesis of N-acetylaspartate in neuronal cells. | lld:pubmed |
| pubmed-article:15987682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15987682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15987682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15987682 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15987682 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:KobayashiKeik... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:SahekiTakeyor... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:IijimaMikioM | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:NakagawaShiro... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:BegumLailaL | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:JalilMd... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:LiMeng XianMX | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:HoriuchiMasah... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:SatrústeguiJo... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:IsashikiYasus... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:PardoBeatrizB | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:RamosMilagros... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:OkuboAkikoA | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:SameshimaMune... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:Del... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:ContrerasLaur... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:MarmolPatrici... | lld:pubmed |
| pubmed-article:15987682 | pubmed:author | pubmed-author:ShimotsuKyoko... | lld:pubmed |
| pubmed-article:15987682 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15987682 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:15987682 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15987682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15987682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15987682 | pubmed:pagination | 31333-9 | lld:pubmed |
| pubmed-article:15987682 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15987682 | pubmed:meshHeading | pubmed-meshheading:15987682... | lld:pubmed |
| pubmed-article:15987682 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15987682 | pubmed:articleTitle | Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. | lld:pubmed |
| pubmed-article:15987682 | pubmed:affiliation | Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan. | lld:pubmed |
| pubmed-article:15987682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15987682 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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