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pubmed-article:15980462pubmed:abstractTextThe Fragnostic (http://ffas.burnham.org/Fragnostic) web tool implements a novel and useful view of protein structure space. We mined a non-redundant subset of the PDB for common fragments shared between proteins inhabiting different SCOP folds. Subsequently, we formulated an inter-fold similarity measure based on fragment sharing. Fold space is described as a graph whose nodes are folds between which the edges are drawn depending on the extent of fragment sharing. In this fashion, Fragnostic helps discover meaningful relationships between proteins belonging to different folds, based on sharing similar fragments in the proteins comprising those folds. Distant fold similarity information is supplemented by annotations taken from Gene Ontology, SCOP and CATH. Overall, Fragnostic is a tool which helps discover structural and functional relationships between proteins which are distantly related or seemingly unrelated.lld:pubmed
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pubmed-article:15980462pubmed:authorpubmed-author:GodzikAdamAlld:pubmed
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pubmed-article:15980462pubmed:paginationW249-51lld:pubmed
pubmed-article:15980462pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:15980462pubmed:year2005lld:pubmed
pubmed-article:15980462pubmed:articleTitleFragnostic: walking through protein structure space.lld:pubmed
pubmed-article:15980462pubmed:affiliationThe Burnham Institute 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. idoerg@burnham.orglld:pubmed
pubmed-article:15980462pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15980462pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15980462pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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