| pubmed-article:15956557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0021270 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0205127 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0376558 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:15956557 | lifeskim:mentions | umls-concept:C0439234 | lld:lifeskim |
| pubmed-article:15956557 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:15956557 | pubmed:dateCreated | 2005-6-15 | lld:pubmed |
| pubmed-article:15956557 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-gamma) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in approximately 50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/10(6) peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10(6) PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-gamma responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-gamma responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8+-T-cell responses early in life that are not clearly associated with improved clinical outcomes. | lld:pubmed |
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| pubmed-article:15956557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15956557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15956557 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15956557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15956557 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15956557 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:RichardsonBar... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:OverbaughJuli... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:DongTaoT | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:Mbori-NgachaD... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:FarquharCarey... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:CrudderChrist... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:Rowland-Jones... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:John-StewartG... | lld:pubmed |
| pubmed-article:15956557 | pubmed:author | pubmed-author:LohmanBarbara... | lld:pubmed |
