| pubmed-article:15946939 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C1422257 | lld:lifeskim |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:15946939 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:15946939 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:15946939 | pubmed:dateCreated | 2005-7-25 | lld:pubmed |
| pubmed-article:15946939 | pubmed:abstractText | Smad7 functions as an intracellular antagonist in transforming growth factor-beta (TGF-beta) signaling. In addition to interacting stably with the activated TGF-beta type I receptor (TbetaRI) to prevent phosphorylation of the receptor-regulated Smads (Smad2 and Smad3), Smad7 also induces degradation of the activated TbetaRI through association with different E3 ubiquitin ligases. Using the two-hybrid screen, we identified atrophin 1-interacting protein 4 (AIP4) as an E3 ubiquitin ligase that specifically targets Smad7 for ubiquitin-dependent degradation without affecting the turnover of the activated TbetaRI. Surprisingly, we found that despite the ability to degrade Smad7, AIP4 can inhibit TGF-beta signaling, presumably by enhancing the association of Smad7 with the activated TbetaRI. Consistent with this notion, expression of a catalytic mutant of AIP4, which is unable to induce ubiquitination and degradation of Smad7, also stabilizes the TbetaRI.Smad7 complex, resulting in inhibition of TGF-beta signaling. The ability of AIP4 to enhance the inhibitory function of Smad7 independent of its ubiquitin ligase activity reveals a new mechanism by which E3 ubiquitin ligases may function to turn off TGF-beta signaling. | lld:pubmed |
| pubmed-article:15946939 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15946939 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15946939 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15946939 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15946939 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:Roman-RomanSe... | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:L'HosteSebast... | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:CamonisJacque... | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:AtfiAzeddineA | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:PessahMarciaM | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:FerrandNathal... | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:LallemandFran... | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:SeoSu RyeonSR | lld:pubmed |
| pubmed-article:15946939 | pubmed:author | pubmed-author:RawadiGeorges... | lld:pubmed |
| pubmed-article:15946939 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15946939 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15946939 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:15946939 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15946939 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15946939 | pubmed:pagination | 27645-53 | lld:pubmed |
| pubmed-article:15946939 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15946939 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15946939 | pubmed:articleTitle | AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism. | lld:pubmed |
| pubmed-article:15946939 | pubmed:affiliation | INSERM U482, Hôpital Saint-Antoine, 184 Rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France. | lld:pubmed |
| pubmed-article:15946939 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15946939 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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