| pubmed-article:15945611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15945611 | lifeskim:mentions | umls-concept:C0032176 | lld:lifeskim |
| pubmed-article:15945611 | lifeskim:mentions | umls-concept:C0024480 | lld:lifeskim |
| pubmed-article:15945611 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15945611 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:15945611 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:15945611 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15945611 | pubmed:dateCreated | 2005-6-10 | lld:pubmed |
| pubmed-article:15945611 | pubmed:abstractText | Magnesium sulphate has well known antiplatelet properties. Its effect on leptin-dependent platelet aggregation has not been studied previously. Thus, we performed this ex vivo study to investigate whether magnesium sulphate is able to inhibit leptin-dependent aggregation of human platelets. We obtained platelet rich plasma (PRP) from venous blood samples of 16 healthy male volunteers, and we measured ADP-induced platelet aggregation in the presence of leptin alone (5-500 ng/mL) or leptin and magnesium sulphate (0.25-8 mM). Platelet pre-incubation with leptin led to a significant and dose-dependent increase in ADP-induced platelet aggregation. Magnesium sulphate was able to inhibit the pro-aggregating effect of leptin in a dose-dependent manner. The inhibitory effect was apparent at 1 mM of magnesium sulphate concentration (% maximal aggregation=38.1 +/- 12.2) and reached its maximum at 8 mM (% maximal aggregation=20.0 +/- 7.8). Our results demonstrate that leptin-dependent platelet aggregation is inhibited by magnesium sulphate in a dose-dependent manner. It seems conceivable that the blocking of hydrolysis of phosphoinositide and of intracellular calcium mobilization by magnesium sulphate may be involved in these findings. | lld:pubmed |
| pubmed-article:15945611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15945611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15945611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15945611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15945611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15945611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15945611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15945611 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15945611 | pubmed:issn | 0953-1424 | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:IentileRR | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:LoddoSS | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:CoricaFF | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:CorsonelloAA | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:MalaraAA | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:De DomenicoDD | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:DamianoM CMC | lld:pubmed |
| pubmed-article:15945611 | pubmed:author | pubmed-author:MironeSS | lld:pubmed |
| pubmed-article:15945611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15945611 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15945611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15945611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15945611 | pubmed:pagination | 7-11 | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:meshHeading | pubmed-meshheading:15945611... | lld:pubmed |
| pubmed-article:15945611 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15945611 | pubmed:articleTitle | Effects of magnesium sulphate on leptin-dependent platelet aggregation: an ex vivo study. | lld:pubmed |
| pubmed-article:15945611 | pubmed:affiliation | Italian National Research Centre on Aging (INRCA), 1-87100 Cosenza, Italy. | lld:pubmed |
| pubmed-article:15945611 | pubmed:publicationType | Journal Article | lld:pubmed |
