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pubmed-article:15942884pubmed:abstractTextThe significant impact of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is now recognized. This recognition has led to increased efforts to provide evidence-based, appropriate treatment of AECOPD, to minimize its negative impact. This article reviews the bacterial etiology of AECOPD and clinical trials (both placebo-controlled and antibiotic comparison trials) that support the use of antibiotics for AECOPD, with an emphasis on the role of newer fluoroquinolones for the treatment of patients with this condition. A discussion of patient stratification that permits identification of those who require initial aggressive antibiotic therapy is presented.lld:pubmed
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pubmed-article:15942884pubmed:authorpubmed-author:SethiSanjaySlld:pubmed
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pubmed-article:15942884pubmed:volume41 Suppl 2lld:pubmed
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pubmed-article:15942884pubmed:paginationS177-85lld:pubmed
pubmed-article:15942884pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:15942884pubmed:year2005lld:pubmed
pubmed-article:15942884pubmed:articleTitleMoxifloxacin for the treatment of acute exacerbations of chronic obstructive pulmonary disease.lld:pubmed
pubmed-article:15942884pubmed:affiliationDivision of Pulmonary, Critical Care and Sleep Medicine, State University of New York, and Department of Veterans Affairs, Western New York Healthcare System, Buffalo, New York, USA. ssethi@buffalo.edulld:pubmed
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