| pubmed-article:15922395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15922395 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15922395 | lifeskim:mentions | umls-concept:C0449475 | lld:lifeskim |
| pubmed-article:15922395 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:15922395 | lifeskim:mentions | umls-concept:C0442335 | lld:lifeskim |
| pubmed-article:15922395 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15922395 | pubmed:dateCreated | 2005-6-27 | lld:pubmed |
| pubmed-article:15922395 | pubmed:abstractText | Some viruses display enhanced infection for Fc receptor (FcR)-positive cell types when complexed with virus-specific immunoglobulin (Ig). This process has been termed antibody-dependent enhancement of viral infection (ADE). We reasoned that the mechanism of ADE could be exploited and adapted to target alphavirus-based vectors to FcR-positive cell types. Towards this goal, recombinant Sindbis viruses were constructed that express 1 to 4 immunoglobulin-binding domains of protein L (PpL) as N-terminal extensions of the E2 glycoprotein. PpL is a bacterial protein that binds the variable region of antibody kappa light chains from a range of mammalian species. The recombinant viruses incorporated PpL/E2 fusion proteins into the virion structure and recapitulated the species-specific Ig-binding phenotypes of native PpL. Virions reacted with non-immune serum or purified IgG displayed enhanced binding and ADE for several species-matched FcR-positive murine and human cell lines. ADE required virus expression of a functional PpL Ig-binding domain, and appeared to be FcgammaR-mediated. Specifically, ADE did not occur with FcgammaR-negative cells, did not require active complement proteins, and did not occur on FcgammaR-positive murine cell lines when virions were bound by murine IgG-derived F(ab')2 fragments. | lld:pubmed |
| pubmed-article:15922395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15922395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15922395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15922395 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15922395 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:15922395 | pubmed:author | pubmed-author:HeidnerHans... | lld:pubmed |
| pubmed-article:15922395 | pubmed:author | pubmed-author:WilliamsJacqu... | lld:pubmed |
| pubmed-article:15922395 | pubmed:author | pubmed-author:RymanKate DKD | lld:pubmed |
| pubmed-article:15922395 | pubmed:author | pubmed-author:KlimstraWilli... | lld:pubmed |
| pubmed-article:15922395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15922395 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:15922395 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:15922395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15922395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15922395 | pubmed:pagination | 9-21 | lld:pubmed |
| pubmed-article:15922395 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15922395 | pubmed:meshHeading | pubmed-meshheading:15922395... | lld:pubmed |
| pubmed-article:15922395 | pubmed:meshHeading | pubmed-meshheading:15922395... | lld:pubmed |
| pubmed-article:15922395 | pubmed:meshHeading | pubmed-meshheading:15922395... | lld:pubmed |
| pubmed-article:15922395 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15922395 | pubmed:articleTitle | Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. | lld:pubmed |
| pubmed-article:15922395 | pubmed:affiliation | Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. | lld:pubmed |
| pubmed-article:15922395 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15922395 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15922395 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15922395 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15922395 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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