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pubmed-article:15921806pubmed:abstractTextThe Carvedilol or Metoprolol European Trial (COMET) reported a significant survival benefit for carvedilol, a beta1-, beta2- and alpha1-blocker, vs. metoprolol tartrate, a beta1-selective blocker, in patients with mild-to-severe chronic heart failure (CHF). Patients on treatment with metoprolol might benefit from switching to carvedilol.lld:pubmed
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pubmed-article:15921806pubmed:articleTitleExchange of beta-blockers in heart failure patients. Experiences from the poststudy phase of COMET (the Carvedilol or Metoprolol European Trial).lld:pubmed
pubmed-article:15921806pubmed:affiliationDepartment of Cardiology, Ospedale di Cattinara, Strada di Fiume 447, 34100 Trieste, Italy. dilenar@univ.ts.itlld:pubmed
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