Linked Life Data

15920011

Source:http://linkedlifedata.com/resource/pubmed/id/15920011

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pubmed-article:15920011pubmed:abstractTextHeme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature dendritic cells (iDCs) and several but not all freshly isolated rat splenic DC subsets and rat bone marrow-derived iDCs, spontaneously express HO-1. HO-1 expression drastically decreases during human and rat DC maturation induced in vitro. In human tissues, iDCs also express HO-1, whereas mature DCs do not. Induction of HO-1 expression with cobalt protoporphyrin (CoPP) in human and rat DCs inhibits lipopolysaccharide (LPS)-induced phenotypic maturation and secretion of proinflammatory cytokines, resulting in the inhibition of alloreactive T-cell proliferation. CoPP-treated DCs, however, retain the ability to produce the anti-inflammatory cytokine interleukin 10 (IL-10). Reactive oxygen species induced by LPS in DCs were inhibited by induction of HO-1. In conclusion, we identify, for the first time, the capacity of HO-1 to block maturation of DCs and to inhibit proinflammatory and allogeneic immune responses while preserving IL-10 production. This novel immune function for HO-1 may be of interest for the inhibition of immune responses in autoimmune diseases, transplantation, and other conditions involving activation of the immune system.lld:pubmed
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pubmed-article:15920011pubmed:articleTitleHeme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression.lld:pubmed
pubmed-article:15920011pubmed:affiliationINSERM U643, CHRU Nantes, 30 boulevard Jean Monnet, 44093 Nantes, France.lld:pubmed
pubmed-article:15920011pubmed:publicationTypeJournal Articlelld:pubmed
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