| pubmed-article:1590995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1590995 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1590995 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:1590995 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:1590995 | pubmed:dateCreated | 1992-6-26 | lld:pubmed |
| pubmed-article:1590995 | pubmed:abstractText | The most efficient way to ensure self-tolerance in the T-cell repertoire is by intrathymic deletion of self-reactive clones. Antigens not present intrathymically may, however, influence the peripheral T-cell pool in various ways. The may of course activate T cells, provided that these have the correct specificity and affinity and that the antigens are presented in sufficient amounts on professional antigen-presenting cells. They may be ignored by T cells if some of these conditions are not met. In some forms, the antigen may be toleragenic for mature T cells. If the antigens persist in an immunogenic form, unresponsiveness may eventually be imposed as the end result of a powerful immune response. Extrathymic self-antigenic components are generally encountered early in development, and the way in which these influence peripheral T lymphocytes has been studied by transgenic technology. They may be ignored by T cells if they are sequestered from the immune system, or if they are present in low amounts or on nonprofessional antigen-presenting cells which lack the appropriate accessory molecules or signals needed to activate the relevant T-cell subset. On the other hand, some of these self-antigens readily induce anergy in peripheral T cells, which may or may not involve downregulation of antigen receptors and coreceptors. Tolerance in the T-cell repertoire is therefore achieved not only by intrathymic deletion of self-reactive clones but also by several postthymic mechanisms. | lld:pubmed |
| pubmed-article:1590995 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1590995 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1590995 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1590995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1590995 | pubmed:issn | 0732-0582 | lld:pubmed |
| pubmed-article:1590995 | pubmed:author | pubmed-author:MillerJ FJF | lld:pubmed |
| pubmed-article:1590995 | pubmed:author | pubmed-author:MorahanGG | lld:pubmed |
| pubmed-article:1590995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1590995 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1590995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1590995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1590995 | pubmed:pagination | 51-69 | lld:pubmed |
| pubmed-article:1590995 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
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| pubmed-article:1590995 | pubmed:meshHeading | pubmed-meshheading:1590995-... | lld:pubmed |
| pubmed-article:1590995 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1590995 | pubmed:articleTitle | Peripheral T cell tolerance. | lld:pubmed |
| pubmed-article:1590995 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:1590995 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1590995 | pubmed:publicationType | Review | lld:pubmed |
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