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pubmed-article:15908406pubmed:abstractTextThe basis of the rough-to-smooth conversion of Actinobacillus actinomycetemcomitans was examined. Smooth variants often contained mutations at the flp promoter region. Replacing the mutated flp promoter with the wild-type promoter restored the rough phenotype. The expression level of the flp promoter was approximately 100-fold lower in smooth than in rough strains. Mutations of the flp promoter are a cause of the rough-to-smooth conversion.lld:pubmed
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pubmed-article:15908406pubmed:authorpubmed-author:WangYingYlld:pubmed
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pubmed-article:15908406pubmed:articleTitleGenetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans.lld:pubmed
pubmed-article:15908406pubmed:affiliationDivision of Primary Oral Health Care, University of Southern California School of Dentistry, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA.lld:pubmed
pubmed-article:15908406pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15908406pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15908406pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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