| pubmed-article:15896199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0005961 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C1415562 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0019751 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0665952 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:15896199 | lifeskim:mentions | umls-concept:C0445356 | lld:lifeskim |
| pubmed-article:15896199 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15896199 | pubmed:dateCreated | 2005-5-17 | lld:pubmed |
| pubmed-article:15896199 | pubmed:abstractText | Matching of donor and recipient for the class I human leukocyte antigen-C (HLA-C)-encoded natural killer (NK) epitopes has been reported to influence stem-cell (SC) graft outcome, but a consistent picture has not yet emerged. We have analyzed transplant outcome in 104 unrelated SC grafts in relation to NK epitope (C1 and C2) matching and donor killer cell immunoglobulin-like receptor (KIR) genotype. NK epitope mismatching in the rejection direction was strongly associated with an increased probability of rejection subsequent to engraftment. The prevalence of grades III-IV acute graft-vs-host disease (GVHD) was significantly higher and occurred significantly earlier when there was NK epitope mismatching in the GVH direction. Higher transplant-related mortality and lower disease-free survival rates were associated with epitope mismatching regardless of the mismatch direction. A greater number of KIR receptors, both activating and inhibitory, in the donor protected against grades III-IV GVHD and improved survival. | lld:pubmed |
| pubmed-article:15896199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15896199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15896199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15896199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15896199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15896199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15896199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15896199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15896199 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15896199 | pubmed:issn | 0001-2815 | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:SlavinSS | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:BrautbarCC | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:ChristiansenF... | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:WittC SCS | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:NaglerAA | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:De SantisDD | lld:pubmed |
| pubmed-article:15896199 | pubmed:author | pubmed-author:BisharaAA | lld:pubmed |
| pubmed-article:15896199 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15896199 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:15896199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15896199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15896199 | pubmed:pagination | 519-28 | lld:pubmed |
| pubmed-article:15896199 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15896199 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15896199 | pubmed:articleTitle | Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. | lld:pubmed |
| pubmed-article:15896199 | pubmed:affiliation | Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia. | lld:pubmed |
| pubmed-article:15896199 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15896199 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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