| pubmed-article:15895088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15895088 | lifeskim:mentions | umls-concept:C0596991 | lld:lifeskim |
| pubmed-article:15895088 | lifeskim:mentions | umls-concept:C0028944 | lld:lifeskim |
| pubmed-article:15895088 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15895088 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15895088 | pubmed:dateCreated | 2005-5-26 | lld:pubmed |
| pubmed-article:15895088 | pubmed:abstractText | The control of myelination by oligodendrocytes in the CNS is poorly understood. Here we show that LINGO-1 is an important negative regulator of this critical process. LINGO-1 is expressed in oligodendrocytes. Attenuation of its function by dominant-negative LINGO-1, LINGO-1 RNA-mediated interference (RNAi) or soluble human LINGO-1 (LINGO-1-Fc) leads to differentiation and increased myelination competence. Attenuation of LINGO-1 results in downregulation of RhoA activity, which has been implicated in oligodendrocyte differentiation. Conversely, overexpression of LINGO-1 leads to activation of RhoA and inhibition of oligodendrocyte differentiation and myelination. Treatment of oligodendrocyte and neuron cocultures with LINGO-1-Fc resulted in highly developed myelinated axons that have internodes and well-defined nodes of Ranvier. The contribution of LINGO-1 to myelination was verified in vivo through the analysis of LINGO-1 knockout mice. The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination. | lld:pubmed |
| pubmed-article:15895088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15895088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15895088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15895088 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15895088 | pubmed:issn | 1097-6256 | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:UsaSS | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:MillerRobert... | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:PepinskyR... | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:HeZhigangZ | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:JungVincentV | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:ShaoZhaohuiZ | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:ScottMartin... | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:McCoyJohn MJM | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:ZhangMingdiM | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:LevesqueMelis... | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:SahDinahD | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:ThillGregG | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:LeeXinhuaX | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:ChangJufangJ | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:Shulag-Morska... | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:HessionCathyC | lld:pubmed |
| pubmed-article:15895088 | pubmed:author | pubmed-author:TrappBruceB | lld:pubmed |
| pubmed-article:15895088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15895088 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:15895088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15895088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15895088 | pubmed:pagination | 745-51 | lld:pubmed |
| pubmed-article:15895088 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15895088 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15895088 | pubmed:articleTitle | LINGO-1 negatively regulates myelination by oligodendrocytes. | lld:pubmed |
| pubmed-article:15895088 | pubmed:affiliation | Department of Discovery Biology, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA. sha.mi@biogenidec.com | lld:pubmed |
| pubmed-article:15895088 | pubmed:publicationType | Journal Article | lld:pubmed |
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