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pubmed-article:15887027pubmed:abstractTextThe presence of isolated tumor cells in the bone marrow (ITC-BM) is an independent prognostic factor in all stages of breast cancer. Both the expression/amplification of human epithelial growth factor receptor 2 (HER2) and Topoisomerase IIalpha (TOP IIa), a key enzyme of DNA replication and main target of anthracyclins, in breast cancer tissue seem to have predictive value regarding the effectiveness of systemic therapies.lld:pubmed
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pubmed-article:15887027pubmed:articleTitleIsolated tumor cells in the bone marrow (ITC-BM) of breast cancer patients before and after anthracyclin based therapy: influenced by the HER2- and Topoisomerase IIalpha-status of the primary tumor?lld:pubmed
pubmed-article:15887027pubmed:affiliationI. Frauenklinik, Klinikum der Ludwig-Maximilians-Universität, Maistrasse 11, 80337 Munich, Germany. Christian.Schindlbeck@med.uni-muenchen.delld:pubmed
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