| pubmed-article:15883587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C0366686 | lld:lifeskim |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C1415050 | lld:lifeskim |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C1428184 | lld:lifeskim |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15883587 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:15883587 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15883587 | pubmed:dateCreated | 2005-7-25 | lld:pubmed |
| pubmed-article:15883587 | pubmed:abstractText | We report a novel combination of factors that explains almost 60% of variable response to warfarin. Warfarin is a widely used anticoagulant, which acts through interference with vitamin K epoxide reductase that is encoded by VKORC1. In the next step of the vitamin K cycle, gamma-glutamyl carboxylase encoded by GGCX uses reduced vitamin K to activate clotting factors. We genotyped 201 warfarin-treated patients for common polymorphisms in VKORC1 and GGCX. All the five VKORC1 single-nucleotide polymorphisms covary significantly with warfarin dose, and explain 29-30% of variance in dose. Thus, VKORC1 has a larger impact than cytochrome P450 2C9, which explains 12% of variance in dose. In addition, one GGCX SNP showed a small but significant effect on warfarin dose. Incorrect dosage, especially during the initial phase of treatment, carries a high risk of either severe bleeding or failure to prevent thromboembolism. Genotype-based dose predictions may in future enable personalised drug treatment from the start of warfarin therapy. | lld:pubmed |
| pubmed-article:15883587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15883587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15883587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15883587 | pubmed:issn | 1470-269X | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:HuntSS | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:BentleyDD | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:ErikssonNN | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:DownesKK | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:DYALJ AJA | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:MelhusHH | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:DeloukasPP | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:WadeliusCC | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:WadeliusMM | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:GhoriJJ | lld:pubmed |
| pubmed-article:15883587 | pubmed:author | pubmed-author:WallermanOO | lld:pubmed |
| pubmed-article:15883587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15883587 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15883587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15883587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15883587 | pubmed:pagination | 262-70 | lld:pubmed |
| pubmed-article:15883587 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:meshHeading | pubmed-meshheading:15883587... | lld:pubmed |
| pubmed-article:15883587 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15883587 | pubmed:articleTitle | Common VKORC1 and GGCX polymorphisms associated with warfarin dose. | lld:pubmed |
| pubmed-article:15883587 | pubmed:affiliation | Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden. mia.wadelius@medsci.uu.se | lld:pubmed |
| pubmed-article:15883587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15883587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2677 | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| entrez-gene:79001 | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15883587 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15883587 | lld:pubmed |
