| pubmed-article:15879166 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C0036226 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C0232164 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C0042305 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:15879166 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:15879166 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15879166 | pubmed:dateCreated | 2005-8-16 | lld:pubmed |
| pubmed-article:15879166 | pubmed:abstractText | To study the cardioprotective effects of vanadate on ischemia-reperfusion (I/R) injury, isolated rat hearts perfused at constant flow were subjected to global ischemia for 30 min followed by reperfusion for 30 min. In this experimental model, I/R markedly decreased ventricular developed pressure and increased end-diastolic pressure. Pretreatment of hearts with 4 microM vanadate attenuated I/R-induced cardiac dysfunction. The reduction in sarcoplasmic reticulum (SR) Ca2+ uptake and Ca2+ release, as well as SR protein contents for Ca2+-pump ATPase and Ca2+-release channel, was also prevented by vanadate. Pretreatment of hearts with an antioxidant mixture containing superoxide dismutase + catalase exerted effects similar to those of vanadate in I/R hearts. Postischemic treatment of hearts with vanadate or superoxide dismutase + catalase also had beneficial effects on I/R-induced changes in cardiac performance and SR function. Alterations in cardiac function and SR Ca2+ transport due to an oxyradical-generating system (xanthine + xanthine oxidase) or an oxidant (H2O2) were attenuated by treatment with vanadate. These results suggest that vanadate may exert beneficial effects on cardiac performance and SR function in I/R hearts because of its antioxidant action. | lld:pubmed |
| pubmed-article:15879166 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15879166 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879166 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15879166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879166 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15879166 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15879166 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:15879166 | pubmed:author | pubmed-author:MochizukiSeib... | lld:pubmed |
| pubmed-article:15879166 | pubmed:author | pubmed-author:DhallaNaranja... | lld:pubmed |
| pubmed-article:15879166 | pubmed:author | pubmed-author:TakedaSatoshi... | lld:pubmed |
| pubmed-article:15879166 | pubmed:author | pubmed-author:ElimbanVijaya... | lld:pubmed |
| pubmed-article:15879166 | pubmed:author | pubmed-author:SainiHarjot... | lld:pubmed |
| pubmed-article:15879166 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15879166 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:15879166 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15879166 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15879166 | pubmed:pagination | 999-1005 | lld:pubmed |
| pubmed-article:15879166 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:meshHeading | pubmed-meshheading:15879166... | lld:pubmed |
| pubmed-article:15879166 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15879166 | pubmed:articleTitle | Modification of alterations in cardiac function and sarcoplasmic reticulum by vanadate in ischemic-reperfused rat hearts. | lld:pubmed |
| pubmed-article:15879166 | pubmed:affiliation | Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Ave., Winnipeg, MB, Canada R2H 2A6. | lld:pubmed |
| pubmed-article:15879166 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15879166 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15879166 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879166 | lld:pubmed |
