| pubmed-article:15858820 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0162429 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0036341 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0300791 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C1414145 | lld:lifeskim |
| pubmed-article:15858820 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:15858820 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15858820 | pubmed:dateCreated | 2005-7-5 | lld:pubmed |
| pubmed-article:15858820 | pubmed:abstractText | A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. | lld:pubmed |
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| pubmed-article:15858820 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15858820 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15858820 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15858820 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15858820 | pubmed:issn | 1552-4841 | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:McMahonRobert... | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:BuchananRober... | lld:pubmed |
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| pubmed-article:15858820 | pubmed:author | pubmed-author:MitchellBraxt... | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:AvilaMatthew... | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:ThakerGunvant... | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:WonodiIkwunga... | lld:pubmed |
| pubmed-article:15858820 | pubmed:author | pubmed-author:HongL... | lld:pubmed |
| pubmed-article:15858820 | pubmed:copyrightInfo | Copyright 2005 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:15858820 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15858820 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:15858820 | pubmed:volume | 136B | lld:pubmed |
| pubmed-article:15858820 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15858820 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15858820 | pubmed:pagination | 8-11 | lld:pubmed |
| pubmed-article:15858820 | pubmed:dateRevised | 2008-5-21 | lld:pubmed |
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| pubmed-article:15858820 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15858820 | pubmed:articleTitle | Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia. | lld:pubmed |
| pubmed-article:15858820 | pubmed:affiliation | Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA. ehong@mprc.umaryland.edu | lld:pubmed |
| pubmed-article:15858820 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15858820 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15858820 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15858820 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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