| pubmed-article:15848126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0178987 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15848126 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:15848126 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15848126 | pubmed:dateCreated | 2005-4-25 | lld:pubmed |
| pubmed-article:15848126 | pubmed:abstractText | Chronic airway inflammation may induce subsequent airway hyper-responsiveness (AHR) including pathological alteration of neural activity. Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear. This study evaluates the effects of NT-3 and BDNF on nerve mediated airway contractions in vitro. Tracheal segments from BALB/c J mice were cultured for 4 days with NT-3 or BDNF. Responsiveness to electric field stimulation (EFS) was evaluated in organ-bath and innervation patterns were examined by quantitative immunohistochemistry. In cultured segments the EFS-induced contractions were inhibited by tetrodotoxin or atropine. NT-3 reduced the EFS contractions in a concentration-dependent manner whereas BDNF had no effect. The amount of nerve fibers, found in conjunction with the tracheal smooth muscle, was similar in NT-3 treated and control segments. In conclusion, NT-3 attenuates cholinergic nerve-mediated contractions of airway in vitro. Considering the elevated levels of NT-3 found in asthmatic airways, the findings imply a protective role of NT-3 in AHR. | lld:pubmed |
| pubmed-article:15848126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15848126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15848126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15848126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15848126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15848126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15848126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15848126 | pubmed:month | May | lld:pubmed |
| pubmed-article:15848126 | pubmed:issn | 1569-9048 | lld:pubmed |
| pubmed-article:15848126 | pubmed:author | pubmed-author:UddmanRolfR | lld:pubmed |
| pubmed-article:15848126 | pubmed:author | pubmed-author:CardellLars-O... | lld:pubmed |
| pubmed-article:15848126 | pubmed:author | pubmed-author:AdnerMikaelM | lld:pubmed |
| pubmed-article:15848126 | pubmed:author | pubmed-author:BacharOfirO | lld:pubmed |
| pubmed-article:15848126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15848126 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15848126 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:15848126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15848126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15848126 | pubmed:pagination | 81-9 | lld:pubmed |
| pubmed-article:15848126 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:meshHeading | pubmed-meshheading:15848126... | lld:pubmed |
| pubmed-article:15848126 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15848126 | pubmed:articleTitle | Prolonged exposure to NT-3 attenuates cholinergic nerve-mediated contractions in cultured murine airways. | lld:pubmed |
| pubmed-article:15848126 | pubmed:affiliation | Department of Otorhinolaryngology, Laboratory of Clinical Experimental Allergy Research, Malmö University Hospital, SE-20502 Malmö, Sweden. Ofir.Bachar@oron.mas.lu.se | lld:pubmed |
| pubmed-article:15848126 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15848126 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
