| pubmed-article:15840441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15840441 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15840441 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:15840441 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:15840441 | lifeskim:mentions | umls-concept:C0041538 | lld:lifeskim |
| pubmed-article:15840441 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15840441 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15840441 | pubmed:dateCreated | 2005-4-20 | lld:pubmed |
| pubmed-article:15840441 | pubmed:abstractText | Regulation of the cell cycle is dependent on protein degradation by the ubiquitin-proteasome system. Two major ubiquitin ligases, the anaphase-promoting complex or cyclosome (APC/C) and SCF complex, are responsible for the periodic proteolysis of many regulators of the cell cycle. The receptor component of the SCF complex is one of many F-box proteins, three of which--Skp2, Fbw7, and beta-TrCP--are well characterized and implicated in cell cycle regulation. We have generated mice deficient in Skp2, Fbw7, or beta-TrCP1 and have identified the roles of these proteins in both cell cycle regulation and mouse development. Clinical evidence also suggests that dysregulation of these F-box proteins contributes to human cancers. | lld:pubmed |
| pubmed-article:15840441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15840441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15840441 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15840441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15840441 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15840441 | pubmed:issn | 1084-9521 | lld:pubmed |
| pubmed-article:15840441 | pubmed:author | pubmed-author:NakayamaKeiko... | lld:pubmed |
| pubmed-article:15840441 | pubmed:author | pubmed-author:NakayamaKeiic... | lld:pubmed |
| pubmed-article:15840441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15840441 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:15840441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15840441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15840441 | pubmed:pagination | 323-33 | lld:pubmed |
| pubmed-article:15840441 | pubmed:dateRevised | 2011-5-23 | lld:pubmed |
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| pubmed-article:15840441 | pubmed:meshHeading | pubmed-meshheading:15840441... | lld:pubmed |
| pubmed-article:15840441 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15840441 | pubmed:articleTitle | Regulation of the cell cycle by SCF-type ubiquitin ligases. | lld:pubmed |
| pubmed-article:15840441 | pubmed:affiliation | Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan. | lld:pubmed |
| pubmed-article:15840441 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15840441 | pubmed:publicationType | Review | lld:pubmed |
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