| pubmed-article:15817157 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:15817157 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15817157 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15817157 | pubmed:dateCreated | 2005-4-8 | lld:pubmed |
| pubmed-article:15817157 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:abstractText | MSSP has been identified as a transcription factor that regulates the c-myc gene. MSSP was later found to positively or negatively regulate a variety of genes, including alpha-smooth actin, MHC class I, MHC class 2 and the thyrotropin receptor. The knockout mice for the Mssp gene developed by us revealed that these mice became partially embryonic lethal due to a low concentration of progesterone at E2.5. In this study, we further analyzed Mssp-knockout mice and found that the expression of the Fas gene was repressed, resulting in abrogation of Fas-mediated induction of apoptosis both in Mssp-knockout mice and primary thymocytes. MSSP was then found to stimulate promoter activity of the Fas gene by binding to a region spanning -1035 to -635 in chromatin immunoprecipitation assays. Binding of MSSP in the MSSP-binding sequence, TCTAAT, located in this region was confirmed by mobility shift assays, and deletion of this sequence from the Fas promoter was found to result in loss of MSSP-dependent stimulating activity. The results suggest that MSSP is an important mediator for Fas-induced apoptosis in vivo and in vitro. | lld:pubmed |
| pubmed-article:15817157 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15817157 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15817157 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15817157 | pubmed:month | May | lld:pubmed |
| pubmed-article:15817157 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:15817157 | pubmed:author | pubmed-author:ArigaHiroyosh... | lld:pubmed |
| pubmed-article:15817157 | pubmed:author | pubmed-author:NomuraJunJ | lld:pubmed |
| pubmed-article:15817157 | pubmed:author | pubmed-author:MatsumotoKen-... | lld:pubmed |
| pubmed-article:15817157 | pubmed:author | pubmed-author:Iguchi-ArigaS... | lld:pubmed |
| pubmed-article:15817157 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15817157 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15817157 | pubmed:volume | 305 | lld:pubmed |
| pubmed-article:15817157 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15817157 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15817157 | pubmed:pagination | 324-32 | lld:pubmed |
| pubmed-article:15817157 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
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| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
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| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
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| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:meshHeading | pubmed-meshheading:15817157... | lld:pubmed |
| pubmed-article:15817157 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15817157 | pubmed:articleTitle | Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice. | lld:pubmed |
| pubmed-article:15817157 | pubmed:affiliation | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. | lld:pubmed |
| pubmed-article:15817157 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15817157 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15817157 | lld:pubmed |
