| pubmed-article:15814796 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:15814796 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:15814796 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15814796 | pubmed:dateCreated | 2005-4-7 | lld:pubmed |
| pubmed-article:15814796 | pubmed:abstractText | Opioid mu- and delta-receptors are present on the central terminals of primary afferents, where they are thought to inhibit neurotransmitter release. This mechanism may mediate analgesia produced by spinal opiates; however, when they used neurokinin 1 receptor (NK1R) internalization as an indicator of substance P release, Trafton et al. (1999) noted that this evoked internalization was altered only modestly by morphine delivered intrathecally at spinal cord segment S1-S2. We reexamined this issue by studying the effect of opiates on NK1R internalization in spinal cord slices and in vivo. In slices, NK1R internalization evoked by dorsal root stimulation at C-fiber intensity was abolished by the mu agonist [D-Ala2, N-Me-Phe4, Gly-ol5]-enkephalin (DAMGO) (1 microM) and decreased by the delta agonist [D-Phe2,5]-enkephalin (DPDPE) (1 microM). In vivo, hindpaw compression induced NK1R internalization in ipsilateral laminas I-II. This evoked internalization was significantly reduced by morphine (60 nmol), DAMGO (1 nmol), and DPDPE (100 nmol), but not by the kappa agonist trans-(1S,2S)-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide hydrochloride (200 nmol), delivered at spinal cord segment L2 using intrathecal catheters. These doses of the mu and delta agonists were equi-analgesic as measured by a thermal escape test. Lower doses neither produced analgesia nor inhibited NK1R internalization. In contrast, morphine delivered by percutaneous injections at S1-S2 had only a modest effect on thermal escape, even at higher doses. Morphine decreased NK1R internalization after systemic delivery, but at a dose greater than that necessary to produce equivalent analgesia. All effects were reversed by naloxone. These results indicate that lumbar opiates inhibit noxious stimuli-induced neurotransmitter release from primary afferents at doses that are confirmed behaviorally as analgesic. | lld:pubmed |
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| pubmed-article:15814796 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15814796 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814796 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15814796 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15814796 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15814796 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:YakshTony LTL | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:SongBingbingB | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:CodeluppiSimo... | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:KondoIchiroI | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:HuaXiao-YingX... | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:MarvizonJuan... | lld:pubmed |
| pubmed-article:15814796 | pubmed:author | pubmed-author:SalgadoFrance... | lld:pubmed |
| pubmed-article:15814796 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15814796 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15814796 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:15814796 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15814796 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15814796 | pubmed:pagination | 3651-60 | lld:pubmed |
| pubmed-article:15814796 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15814796 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15814796 | pubmed:articleTitle | Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. | lld:pubmed |
| pubmed-article:15814796 | pubmed:affiliation | Department of Anesthesiology, University of California-San Diego, La Jolla, California 92093, USA. | lld:pubmed |
| pubmed-article:15814796 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15814796 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15814796 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15814796 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15814796 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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