| pubmed-article:15795285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0019378 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0680220 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C1519889 | lld:lifeskim |
| pubmed-article:15795285 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:15795285 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15795285 | pubmed:dateCreated | 2005-3-29 | lld:pubmed |
| pubmed-article:15795285 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons infected with clade B virus. Moreover, HLA-A2-restricted responses are largely absent in the acute phase of infection as the viral load is being reduced, suggesting that circulating viruses may lack immunodominant epitopes targeted through HLA-A2. Here we demonstrate an A2-restricted epitope within Vpr (Vpr59-67) that is targeted by acute-phase HIV-1-specific CD8+ T cells, but only in a subset of persons expressing HLA-A2. Individuals in the acute stage of infection with viruses containing the most common current sequence within this epitope (consensus sequence) were unable to mount epitope-specific T-cell responses, whereas subjects infected with the less frequent I60L variant all developed these responses. The I60L variant epitope was a stronger binder to HLA-A2 and was recognized by epitope-specific T cells at lower peptide concentrations than the consensus sequence epitope. These data demonstrate that HLA-A2 is capable of contributing to the acute-phase cytotoxic T-lymphocyte response in infected subjects, but that most currently circulating viruses lack a dominant immunogenic epitope presented by this allele, and suggest that immunodominant epitopes restricted by common HLA alleles may be lost as the epidemic matures. | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15795285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15795285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15795285 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15795285 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:AllenTodd MTM | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:WalkerBruce... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:LichterfeldMa... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:YuXu GXG | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:AddoMarylyn... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:BranderChrist... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:GoulderPhilip... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:RosenbergEric... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:AltfeldMarcus... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:FrahmNicoleN | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:SetteAlessand... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:AlterGalitG | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:RathodAlmasA | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:SidneyJohnJ | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:HarlowJasonJ | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:MotheBianca... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:KalifeElizabe... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:PerkinsBethB | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:ReyorLaura... | lld:pubmed |
| pubmed-article:15795285 | pubmed:author | pubmed-author:RobinsonLoren... | lld:pubmed |
| pubmed-article:15795285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15795285 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:15795285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15795285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15795285 | pubmed:pagination | 5000-5 | lld:pubmed |
| pubmed-article:15795285 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:meshHeading | pubmed-meshheading:15795285... | lld:pubmed |
| pubmed-article:15795285 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15795285 | pubmed:articleTitle | The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. | lld:pubmed |
