| pubmed-article:15761016 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15761016 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:15761016 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15761016 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15761016 | lifeskim:mentions | umls-concept:C1416985 | lld:lifeskim |
| pubmed-article:15761016 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
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| pubmed-article:15761016 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15761016 | pubmed:dateCreated | 2005-6-21 | lld:pubmed |
| pubmed-article:15761016 | pubmed:abstractText | Multiple myeloma is a malignancy of plasma cells. Vaccine immunotherapy is among the novel therapeutic strategies under investigation for this disease. To identify myeloma-associated antigens as potential targets for vaccine immunotherapy, we surveyed a comprehensive panel of bone marrow specimens from patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma for expression of cancer-testis (CT) antigens. Immunohistochemistry (IHC) demonstrated that 82% of stage-III myeloma specimens expressed the CT antigen CT7 (also known as melanoma antigen C1 [MAGE-C1]) and 70% expressed MAGE-A3/6. Messenger RNA for CT7 and MAGE-A family members was detected in 87% and 100% of stage-III samples, respectively. CT7 protein expression increased with advanced stage of disease. Higher levels of CT7 and MAGE-A3/6 proteins also correlated with elevated plasma-cell proliferation. These results show that CT7 and MAGE-A3/6 are promising myeloma-associated antigens for application in vaccine immunotherapy. Furthermore, the common expression and correlation with proliferation suggest a possible pathogenic role for these proteins in myeloma. | lld:pubmed |
| pubmed-article:15761016 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15761016 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15761016 | pubmed:month | Jul | lld:pubmed |
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| pubmed-article:15761016 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:15761016 | pubmed:owner | NLM | lld:pubmed |
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| pubmed-article:15761016 | pubmed:pagination | 167-74 | lld:pubmed |
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| pubmed-article:15761016 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15761016 | pubmed:articleTitle | The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation. | lld:pubmed |
| pubmed-article:15761016 | pubmed:affiliation | New York Branch, Ludwig Institute for Cancer Research, New York, NY, USA. | lld:pubmed |
| pubmed-article:15761016 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15761016 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15761016 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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