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pubmed-article:15760133pubmed:abstractText[reaction: see text] A concise, modular approach for the synthesis of [1,2,4]triazolo[4,3-alpha]piperazines via condensation of highly reactive chloromethyloxadiazoles with ethylenediamines is described. NMR studies of this reaction provide evidence that suggests a novel activation mechanism for electron-deficient chloromethyloxadiazoles.lld:pubmed
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pubmed-article:15760133pubmed:articleTitleSynthesis of [1,2,4]triazolo[4,3-alpha]piperazines via highly reactive chloromethyloxadiazoles.lld:pubmed
pubmed-article:15760133pubmed:affiliationDepartment of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.lld:pubmed
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