| pubmed-article:15758056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C1012855 | lld:lifeskim |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C1012857 | lld:lifeskim |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C1564995 | lld:lifeskim |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:15758056 | lifeskim:mentions | umls-concept:C1708517 | lld:lifeskim |
| pubmed-article:15758056 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15758056 | pubmed:dateCreated | 2005-6-29 | lld:pubmed |
| pubmed-article:15758056 | pubmed:abstractText | Whole cell patch recording was performed from morphologically identified cone-driven on-off bipolar cells (Cabs) in giant danio retinal slices to study their glutamate receptors and light-evoked responses. Specific agonists were puffed in the presence of cobalt, picrotoxin, and strychnine to identify glutamate receptors on these cells. Most Cabs responded to both the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor agonist kainate and the excitatory amino acid transporter (EAAT) substrate D-aspartate, and both responses were localized to the dendrites. Kainate generated depolarizations whereas D-aspartate had E(rev) close to E(Cl) and generated hyperpolarizations, indicating that the AMPA/kainate receptors are sign-preserving, whereas the EAATs are sign-inverting. In response to white light, some Cabs gave on bipolar cell-like responses whereas others gave off bipolar cell-like ones, but many cells' responses had both on and off bipolar cell components. In response to appropriately colored center-selective stimuli, many Cabs responded to short and long wavelengths with opposite polarities and were thus double color-opponent. The depolarizing components of the responses to white or colored stimuli were suppressed by the EAAT blocker DL-threo-beta-benzyloxyaspartate (TBOA), whereas the hyperpolarizing components were reduced by the AMPA/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX). These results are consistent with the hypothesis that both EAATs and AMPA/kainate receptors are involved in the generation of light-evoked responses in Cabs and that they confer these cells with on and off bipolar cell properties, respectively. Cabs can generate double color-opponent center responses by receiving inputs from certain cones through EAATs and from other cones through AMPA/kainate receptors. | lld:pubmed |
| pubmed-article:15758056 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15758056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15758056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15758056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15758056 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15758056 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:15758056 | pubmed:author | pubmed-author:DowlingJohn... | lld:pubmed |
| pubmed-article:15758056 | pubmed:author | pubmed-author:WongKwoon YKY | lld:pubmed |
| pubmed-article:15758056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15758056 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:15758056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15758056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15758056 | pubmed:pagination | 265-72 | lld:pubmed |
| pubmed-article:15758056 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15758056 | pubmed:meshHeading | pubmed-meshheading:15758056... | lld:pubmed |
| pubmed-article:15758056 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15758056 | pubmed:articleTitle | Retinal bipolar cell input mechanisms in giant danio. III. ON-OFF bipolar cells and their color-opponent mechanisms. | lld:pubmed |
| pubmed-article:15758056 | pubmed:affiliation | Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA. Kwoon_Wong@brown.edu | lld:pubmed |
| pubmed-article:15758056 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15758056 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15758056 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15758056 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15758056 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15758056 | lld:pubmed |
