Linked Life Data

15734993

Source:http://linkedlifedata.com/resource/pubmed/id/15734993

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pubmed-article:15734993pubmed:abstractTextThe bone is the third most common site of cancer metastasis. To invade the bone, tumor cells produce osteoclast-activating factors that increase bone resorption by osteoclasts. Here we report that human neuroblastoma cells that form osteolytic lesions in vivo do not produce osteoclast-activating factors but rather stimulate osteoclast activity in the presence of human bone marrow mesenchymal stem cells. This alternative pathway of osteoclast activation involves a nonadhesive interaction between neuroblastoma cells and bone marrow mesenchymal stem cells. Stimulated bone marrow mesenchymal stem cells express markedly increased levels of interleukin-6, which is then responsible for osteoclast activation. This report describes a critical role of bone marrow mesenchymal stem cells in bone destruction in cancer.lld:pubmed
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pubmed-article:15734993pubmed:dateRevised2010-12-28lld:pubmed
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pubmed-article:15734993pubmed:articleTitleBone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells.lld:pubmed
pubmed-article:15734993pubmed:affiliationDivision of Hematology-Oncology, Department of Pediatrics, Keck School of Medicine, USA.lld:pubmed
pubmed-article:15734993pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15734993pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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