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pubmed-article:15731895pubmed:abstractTextL: -Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor families. The development of selective ligands, including competitive agonists and antagonists and positive and negative allosteric modulators, has enabled investigation of the functional roles of glutamate receptor family members.lld:pubmed
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pubmed-article:15731895pubmed:articleTitleIonotropic and metabotropic glutamate receptor structure and pharmacology.lld:pubmed
pubmed-article:15731895pubmed:affiliationPsychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK. james_n_kew@gsk.comlld:pubmed
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