| pubmed-article:1572691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1572691 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:1572691 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:1572691 | lifeskim:mentions | umls-concept:C0017817 | lld:lifeskim |
| pubmed-article:1572691 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1572691 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1572691 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1572691 | pubmed:dateCreated | 1992-6-1 | lld:pubmed |
| pubmed-article:1572691 | pubmed:abstractText | We have previously shown that cellular glutathione (GSH) regulates the T-cell proliferative activity of interleukin-2 (IL-2). Here, we examined whether and how GSH affects the activity of interleukin-4 (IL-4) on murine cytotoxic T cells. CT.4R, a T-cell line that is responsive to both IL-4 and IL-2, was used as a model. Although GSH alone had little effect on the thymidine incorporation of CT.4R cells, it enhanced the response of CT.4R to IL-4 and increased the level of thymidine incorporation up to more than 60-fold in a concentration-dependent manner. GSH affected the binding of IL-4 to cellular receptors. Scatchard plot analysis showed that GSH treatment did not change the dissociation constant significantly; however, it increased the receptor number from 1173 +/- 126 to 2112 +/- 492 molecules per cell. Internalization and degradation studies of IL-4 showed that the amount of IL-4 internalized and degraded in the GSH-treated cells was about twofold higher than those in the cells without GSH treatment. These results suggest that GSH regulates the binding, internalization, degradation and T-cell proliferative activity of IL-4; alteration of cellular GSH levels may thus affect the growth and replication of cytotoxic T cells through growth stimulating cytokines such as IL-2 and IL-4. | lld:pubmed |
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| pubmed-article:1572691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1572691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1572691 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1572691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1572691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1572691 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1572691 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1572691 | pubmed:author | pubmed-author:LeeNN | lld:pubmed |
| pubmed-article:1572691 | pubmed:author | pubmed-author:FinbloomD SDS | lld:pubmed |
| pubmed-article:1572691 | pubmed:author | pubmed-author:LiangS MSM | lld:pubmed |
| pubmed-article:1572691 | pubmed:author | pubmed-author:LiangC MCM | lld:pubmed |
| pubmed-article:1572691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1572691 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:1572691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1572691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1572691 | pubmed:pagination | 435-40 | lld:pubmed |
| pubmed-article:1572691 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1572691 | pubmed:meshHeading | pubmed-meshheading:1572691-... | lld:pubmed |
| pubmed-article:1572691 | pubmed:meshHeading | pubmed-meshheading:1572691-... | lld:pubmed |
| pubmed-article:1572691 | pubmed:meshHeading | pubmed-meshheading:1572691-... | lld:pubmed |
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| pubmed-article:1572691 | pubmed:meshHeading | pubmed-meshheading:1572691-... | lld:pubmed |
| pubmed-article:1572691 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1572691 | pubmed:articleTitle | Regulation by glutathione of interleukin-4 activity on cytotoxic T cells. | lld:pubmed |
| pubmed-article:1572691 | pubmed:affiliation | Division of Cytokine Biology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1572691 | pubmed:publicationType | Journal Article | lld:pubmed |
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