| pubmed-article:15723296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C0286648 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C0023907 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:15723296 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15723296 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15723296 | pubmed:dateCreated | 2005-2-28 | lld:pubmed |
| pubmed-article:15723296 | pubmed:abstractText | Toll-like receptors (TLRs) act as innate immune signal sensors and play central roles in host defense. Myeloid differentiation factor (MyD) 88 is a common adaptor molecule required for signaling mediated by TLRs. When the receptors are activated, cells bearing TLRs produce various proinflammatory cytokines in a MyD88-dependent manner. Liver regeneration following partial hepatectomy (PH) requires innate immune responses, particularly interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production by Kupffer cells, although the recognition and activation processes are still unknown. We investigated whether TLR/MyD88 signaling is critical for induction of innate immune responses after PH. In Myd88(-/-) mice after PH, induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of STAT3 in the liver, and production of TNF-alpha/IL-6 by and activation of NF-kappaB in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration. However, TLR2, 4 and 9, which recognize gram-negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88-mediated pathways. In conclusion, the TLR/MyD88 pathway is essential for incidental liver restoration, particularly its early phase. | lld:pubmed |
| pubmed-article:15723296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15723296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15723296 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15723296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15723296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15723296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15723296 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15723296 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:KishimotoTada... | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:IimuroYujiY | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:NakaTetsujiT | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:TsutsuiHiroko... | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:NakanishiKenj... | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:FujimotoJiroJ | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:SekiEkihiroE | lld:pubmed |
| pubmed-article:15723296 | pubmed:author | pubmed-author:SonGakuheiG | lld:pubmed |
| pubmed-article:15723296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15723296 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:15723296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15723296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15723296 | pubmed:pagination | 443-50 | lld:pubmed |
| pubmed-article:15723296 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15723296 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15723296 | pubmed:articleTitle | Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. | lld:pubmed |
| pubmed-article:15723296 | pubmed:affiliation | First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan. | lld:pubmed |
| pubmed-article:15723296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15723296 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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