pubmed-article:15721259 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15721259 | lifeskim:mentions | umls-concept:C0012892 | lld:lifeskim |
pubmed-article:15721259 | lifeskim:mentions | umls-concept:C0034767 | lld:lifeskim |
pubmed-article:15721259 | lifeskim:mentions | umls-concept:C0547040 | lld:lifeskim |
pubmed-article:15721259 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:15721259 | pubmed:dateCreated | 2005-2-21 | lld:pubmed |
pubmed-article:15721259 | pubmed:abstractText | A hallmark of the Escherichia coli SOS response is the large increase in mutations caused by translesion synthesis (TLS). TLS requires DNA polymerase V (UmuD'2C) and RecA. Here, we show that pol V and RecA interact by two distinct mechanisms. First, pol V binds to RecA in the absence of DNA and ATP and second, through its UmuD' subunit, requiring DNA and ATP without ATP hydrolysis. TLS occurs in the absence of a RecA nucleoprotein filament but is inhibited in its presence. Therefore, a RecA nucleoprotein filament is unlikely to be required for SOS mutagenesis. Pol V activity is severely diminished in the absence of RecA or in the presence of RecA1730, a mutant defective for pol V mutagenesis in vivo. Pol V activity is strongly enhanced with RecA mutants constitutive for mutagenesis in vivo, suggesting that RecA is an obligate accessory factor that activates pol V for SOS mutagenesis. | lld:pubmed |
pubmed-article:15721259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15721259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:15721259 | pubmed:language | eng | lld:pubmed |
pubmed-article:15721259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15721259 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15721259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:15721259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15721259 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15721259 | pubmed:month | Feb | lld:pubmed |
pubmed-article:15721259 | pubmed:issn | 1097-2765 | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:WymanClaireC | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:GoodmanMyron... | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:WoodgateRoger... | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:CoxMichael... | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:LeslieKrisK | lld:pubmed |
pubmed-article:15721259 | pubmed:author | pubmed-author:SchlacherKath... | lld:pubmed |
pubmed-article:15721259 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15721259 | pubmed:day | 18 | lld:pubmed |
pubmed-article:15721259 | pubmed:volume | 17 | lld:pubmed |
pubmed-article:15721259 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15721259 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15721259 | pubmed:pagination | 561-72 | lld:pubmed |
pubmed-article:15721259 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:15721259 | pubmed:year | 2005 | lld:pubmed |
pubmed-article:15721259 | pubmed:articleTitle | DNA polymerase V and RecA protein, a minimal mutasome. | lld:pubmed |
pubmed-article:15721259 | pubmed:affiliation | Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. | lld:pubmed |
pubmed-article:15721259 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15721259 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:15721259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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