| pubmed-article:15716506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C1426957 | lld:lifeskim |
| pubmed-article:15716506 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:15716506 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15716506 | pubmed:dateCreated | 2005-5-25 | lld:pubmed |
| pubmed-article:15716506 | pubmed:abstractText | The decapping of eukaryotic mRNAs is a key step in their degradation. The heteroheptameric Lsm1p-7p complex is a general activator of decapping and also functions in protecting the 3' ends of deadenylated mRNAs from a 3'-trimming reaction. Lsm1p is the unique member of the Lsm1p-7p complex, distinguishing that complex from the functionally different Lsm2p-8p complex. To understand the function of Lsm1p, we constructed a series of deletion and point mutations of the LSM1 gene and examined their effects on phenotype. These studies revealed the following: (i) Mutations affecting the predicted RNA-binding and inter-subunit interaction residues of Lsm1p led to impairment of mRNA decay, suggesting that the integrity of the Lsm1p-7p complex and the ability of the Lsm1p-7p complex to interact with mRNA are important for mRNA decay function; (ii) mutations affecting the predicted RNA contact residues did not affect the localization of the Lsm1p-7p complex to the P-bodies; (iii) mRNA 3'-end protection could be indicative of the binding of the Lsm1p-7p complex to the mRNA prior to activation of decapping, since all the mutants defective in mRNA 3' end protection were also blocked in mRNA decay; and (iv) in addition to the Sm domain, the C-terminal domain of Lsm1p is also important for mRNA decay function. | lld:pubmed |
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| pubmed-article:15716506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15716506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15716506 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15716506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
