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pubmed-article:15715273pubmed:dateCreated2005-2-17lld:pubmed
pubmed-article:15715273pubmed:abstractTextParenteral nutrition (PN) decreases gut-associated lymphoid tissue (GALT), the intestinal IgA stimulating cytokines IL-4 and IL-10 in gut homogenates, intestinal IgA levels and the expression of Peyer patch (PP) mucosal cellular adhesion molecule-1 (MAdCAM-1), an adhesion molecule found on the high endothelial venules of PP and other tissues. IL-4 in PP stimulates MAdCAM expression in vitro. MAdCAM-1 blockade with MECA-367 reduces GALT cell populations to PN levels but maintains intestinal IgA levels if the animals are chow fed. This study compares IL-4 levels in PP of chow and PN fed mice and measures the effects of MAdCAM blockade on IL-4 and IL-10 levels in gut homogenates of chow fed mice. We hypothesized that in vivo IL-4 levels drop in PP of PN fed mice and IL-4 and IL-10 levels are maintained after MAdCAM-1 blockade in chow fed mice.lld:pubmed
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pubmed-article:15715273pubmed:authorpubmed-author:KudskKenneth...lld:pubmed
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pubmed-article:15715273pubmed:authorpubmed-author:ReeseShannon...lld:pubmed
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pubmed-article:15715273pubmed:volume29lld:pubmed
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pubmed-article:15715273pubmed:pagination44-7lld:pubmed
pubmed-article:15715273pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15715273pubmed:articleTitleEnteral feeding preserves gut Th-2 cytokines despite mucosal cellular adhesion molecule-1 blockade.lld:pubmed
pubmed-article:15715273pubmed:affiliationVeterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital Madison, Wisconsin, USA.lld:pubmed
pubmed-article:15715273pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15715273pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15715273pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed