| pubmed-article:15707406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0172537 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:15707406 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:15707406 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15707406 | pubmed:dateCreated | 2005-2-14 | lld:pubmed |
| pubmed-article:15707406 | pubmed:abstractText | Recent studies have shown an increased expression of several matrix metalloproteinases (MMP) during cardiac, renal and pulmonary allograft rejection. To further define the roles of MMP-2 and MMP-9 in the pathogenesis of cardiac allograft rejection, BALB/c cardiac allografts were transplanted into MMP-2-deficient (-/-) and MMP-9-/- mice. Allografts rejected by wild-type mice revealed a significant increase in MMP-2 and MMP-9 expression. MMP-2-deficiency significantly prolonged allograft survival time. Functioning allografts harvested from MMP-2-/- mice showed lower cellular infiltration and fibrosis than rejected allografts harvested from MMP-2+/+ mice at the same time. In contrast, MMP-9-deficiency significantly decreased allograft survival time. Functioning allografts harvested from MMP-9+/+ mice showed lower cellular infiltration and fibrosis than rejected allografts harvested from MMP-9-/- mice at the same time. MMP-2-/- recipients showed decreased T-cell alloreactivity mediated by a defect in dendritic cell stimulatory and T-cell responsive capacities. In contrast, MMP-9-/- recipients showed increased T-cell alloreactivity mediated by a significant increased in dendritic cell stimulatory and T-cell responsive capacities. These results indicate that MMP2 and MMP-9 play significantly different roles in the process of cardiac allograft rejection. | lld:pubmed |
| pubmed-article:15707406 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15707406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15707406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15707406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15707406 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15707406 | pubmed:issn | 1600-6135 | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:TomP APA | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:SeniorRobert... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:ShipleyJ... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:ItoharaShigey... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:JaramilloAndr... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:RogersJoseph... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:MoazamiNaderN | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:CampbellLacey... | lld:pubmed |
| pubmed-article:15707406 | pubmed:author | pubmed-author:RamachandranS... | lld:pubmed |
| pubmed-article:15707406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15707406 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15707406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15707406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15707406 | pubmed:pagination | 517-28 | lld:pubmed |
| pubmed-article:15707406 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:meshHeading | pubmed-meshheading:15707406... | lld:pubmed |
| pubmed-article:15707406 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15707406 | pubmed:articleTitle | Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection. | lld:pubmed |
| pubmed-article:15707406 | pubmed:affiliation | Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA. | lld:pubmed |
| pubmed-article:15707406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15707406 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15707406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15707406 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15707406 | lld:pubmed |
